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This increase in extracellular glutamate causes neighboring healthy motor neurons to die, to burst, and to release more glutamate into extracellular space, which will kill even more neighboring cells.
How the Deanna Protocol® Metabolic Plan Helps Stop Cell Death Caused by Extracellular Glutamate in ALS Does the Deanna Protocol® Metabolic Plan (DP™ Plan) neutralize the excess extracellular glutamate in ALS? The increase in AKG enables their mitochondria to produce enough energy to help keep cells alive, despite their exposure to an unhealthy amount of extracellular glutamate.
AKG usually does not pass through the cell membranes in normal healthy cells. Tedone, they found that the permeability of the cell membrane in diseased or damaged cells changes and allows AKG to permeate the cells.
These substances are AAKG, AKG, GABA, Ubiquinol (Co Q10), Niacin (non-flush), and 5HTP (5-hydroxtrytophane).
Another component of the Winning the Fight Program for ALS consists of ancillary substances, some of which have been found effective in Deanna, but have not yet been proven in a lab, and others of which the National Institutes of Health (NIH) claims maintain the health of the nervous system and muscles.
Vincent Tedone through his research on Amyotrophic Lateral Sclerosis (ALS, or Lou Gehrig's Disease).